| Primary information |
|---|
| ID | 33063 |
| Uniprot ID | O00590 |
| Description | Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly l |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Phosphorylated on serine residues in the C-terminal cytoplasmic tail. |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2; CCL3; CCL3L1; CCL4; CCL5; CCL7; CCL8; CCL11; CCL13; CCL17; CCL22; CCL23; CCL24; SCYA2/MCP-1; SCY3/MIP-1-alpha; SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation; activates a beta-arrestin 1 (ARRB1)-dependent; G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane; increasing its efficiency in chemokine uptake and degradation. By scavenging chemok |
| Length | 384 |
| Molecular Weight | 43443 |
| Reference | 9364936; 9405404; 14 |
| Hormone | NA |
| PDB ID | NA
|