| Primary information |
|---|
| ID | 33062 |
| Uniprot ID | P51679 |
| Description | C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | In natural killer cells; CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues; most probably by beta-adrenergic receptor kinases 1 and 2. |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC; CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS; could mediate hippocampal-neuron survival. |
| Length | 360 |
| Molecular Weight | 41403 |
| Reference | 7642634; 11196669; 1 |
| Hormone | NA |
| PDB ID | NA
|