| Primary information |
|---|
| ID | 33031 |
| Uniprot ID | Q07954 |
| Description | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into- Low-density lipoprotein recep |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]- Cell membrane; Single-pass type |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells |
| Length | 4544 |
| Molecular Weight | 504606 |
| Reference | 3266596; 7534747; 97 |
| Hormone | NA |
| PDB ID | NA
|