Detailed description page of Hmrbase2

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33028 details
Primary information
ID33028
Uniprot IDO60494
DescriptionCubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor)
OrganismHomo sapiens
TxonomyHomo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms
Subcellular LocationApical cell membrane
Developmental StageNA
SimilarityNA
Post Translational ModificationThe precursor is cleaved by a trans-Golgi proteinase furin; removing a propeptide.
FunctionEndocytic receptor which plays a role in lipoprotein; vitamin and iron metabolism by facilitating their uptake
Length3623
Molecular Weight398736
Reference9572993; 15164054; 1
HormoneNA
PDB IDNA