| Primary information |
|---|
| ID | 33027 |
| Uniprot ID | P16671 |
| Description | Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (G |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | N-glycosylated and O-glycosylated with a ratio of 2-1. |
| Function | Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin; fibronectin; collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL); anionic phospholipids; long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously; the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis; inflammatory response; fatty acid metabolism; taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells; thus participating in muscle lipid utilization; adipose energy storage; and gut fat absorption |
| Length | 472 |
| Molecular Weight | 53053 |
| Reference | 2473841; 7693552; 75 |
| Hormone | NA |
| PDB ID | NA
|