| Primary information |
|---|
| ID | 33012 |
| Uniprot ID | Q9UKV5 |
| Description | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Endoplasmic reticulum membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Palmitoylation of the RING-type zing finger by ZDHHC6 promotes localization to the peripheral endoplasmic reticulum. |
| Function | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins; such as CD3D; CYP3A4; CFTR; INSIG1; SOAT2/ACAT2 and APOB for proteasomal degradation |
| Length | 643 |
| Molecular Weight | 72996 |
| Reference | 10456327; 15489334; |
| Hormone | NA |
| PDB ID | NA
|