| Primary information |
|---|
| ID | 33003 |
| Uniprot ID | Q8NER5 |
| Description | Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate; then bind and activate SMAD transcriptional regulators; SMAD2 and SMAD3. Receptor for activin AB; activin B and NODAL. Plays a role in cell differentiation; growth arrest and apoptosis. |
| Length | 493 |
| Molecular Weight | 54871 |
| Reference | 12063393; 12606401; |
| Hormone | NA |
| PDB ID | NA
|