| Primary information |
|---|
| ID | 32956 |
| Uniprot ID | Q62959 |
| Description | Leptin receptor;LEP-R;Alternative Name- OB receptor;OB-R;Alternative Name- CD_antigen=CD295;Precursor |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Isoform E- Secreted (Probable) |
| Developmental Stage | NA |
| Similarity | Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. |
| Post Translational Modification | On ligand binding; phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11; ERK/FOS activation and; for interaction with SOCS3. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. |
| Function | Receptor for obesity factor (leptin). On ligand binding; mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and; in a hematopoietic pathway; required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway. Isoform A may act to transport leptin to the cerebrospinal fluid. The putative soluble isoform E could function as a transport protein. |
| Length | 1162 |
| Molecular Weight | 130833 |
| Reference | NA |
| Hormone | P50596 |
| PDB ID | NA
|