| Primary information |
|---|
| ID | 31643 |
| Uniprot ID | P43115 |
| Description | Prostaglandin E2 receptor EP3 subtype;PGE receptor; EP3 subtype;PGE2-R;Alternative Name- Prostanoid EP3 receptor |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Post Translational Modification | NA |
| Function | Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion; modulation of neurotransmitter release in central and peripheral neurons; inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins; and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems. |
| Length | 390 |
| Molecular Weight | 43310 |
| Reference | NA |
| Hormone | 1365; 1366 |
| PDB ID | NA
|