| Primary information |
|---|
| ID | 31638 |
| Uniprot ID | P25090 |
| Description | N-formyl peptide receptor 2;Alternative Name- FMLP-related receptor I;FMLP-R-I;Alternative Name- Formyl peptide receptor-like 1;Alternative Name- Lipoxin A4 receptor;LXA4 receptor;Alternative Name- RF |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Post Translational Modification | NA |
| Function | Low affinity receptor for N-formyl-methionyl peptides; which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). |
| Length | 351 |
| Molecular Weight | 38964 |
| Reference | NA |
| Hormone | 1359 |
| PDB ID | NA
|