| Primary information |
|---|
| ID | 31635 |
| Uniprot ID | Q9Y271 |
| Description | Cysteinyl leukotriene receptor 1;CysLTR1;Alternative Name- Cysteinyl leukotriene D4 receptor;LTD4 receptor;Alternative Name- HG55;Alternative Name- HMTMF81 |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Post Translational Modification | NA |
| Function | Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle; edema; eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 LTE4 = LTC4 LTB4. |
| Length | 337 |
| Molecular Weight | 38541 |
| Reference | NA |
| Hormone | 1344; 1345; 1346; 1347; 1348; 1349; 1350; 1351; 13 |
| PDB ID | NA
|