| Primary information |
|---|
| ID | 31496 |
| Uniprot ID | O16845 |
| Description | Protein tailless;Alternative Name- Nuclear receptor subfamily 2 group E member 2 |
| Organism | Drosophila virilis |
| Txonomy | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila. |
| Subcellular Location | Nucleus (Potential) |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate. |
| Length | 450 |
| Molecular Weight | 50323 |
| Reference | NA |
| Hormone | NA |
| PDB ID | NA
|