| Primary information |
|---|
| ID | 31494 |
| Uniprot ID | Q95L87 |
| Description | Steroidogenic factor 1;STF-1;SF-1;Alternative Name- Nuclear receptor subfamily 5 group A member 1 |
| Organism | Macropus eugenii |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Metatheria; Diprotodontia; Macropodidae; Macropus. |
| Subcellular Location | Nucleus |
| Developmental Stage | Expressed by both ovaries and testes on the day of birth; just prior to the onset of testicular differentiation; until at least 8 days after birth by which time the ovary also has begun to sexually differentiate. |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | Acetylation stimulates the transcriptional activity. |
| Function | Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A; CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO-NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup; in particular PI(3;4)P2 and PI(3;4;5)P3. |
| Length | 463 |
| Molecular Weight | 51869 |
| Reference | NA |
| Hormone | NA |
| PDB ID | NA
|