| Primary information |
|---|
| ID | 31432 |
| Uniprot ID | O88275 |
| Description | Peroxisome proliferator-activated receptor gamma;PPAR-gamma;Alternative Name- Nuclear receptor subfamily 1 group C member 3 |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | Phosphorylated by MAPK. The phosphorylation inhibits PPAR gamma activity. |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand; the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. |
| Length | 505 |
| Molecular Weight | 57567 |
| Reference | NA |
| Hormone | 1044 |
| PDB ID | NA
|