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31428 details
Primary information
ID31428
Uniprot IDO18924
DescriptionPeroxisome proliferator-activated receptor gamma;PPAR-gamma;Alternative Name- Nuclear receptor subfamily 1 group C member 3
OrganismMacaca mulatta
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Subcellular LocationNucleus
Developmental StageNA
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post Translational ModificationNA
FunctionReceptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand; the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
Length505
Molecular Weight57590
ReferenceNA
Hormone1044
PDB IDNA