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31418 details
Primary information
ID31418
Uniprot IDP23204
DescriptionPeroxisome proliferator-activated receptor alpha;PPAR-alpha;Alternative Name- Nuclear receptor subfamily 1 group C member 1
OrganismMus musculus
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular LocationNucleus
Developmental StageIt appears first at 13.5 dpc and increases until birth.
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post Translational ModificationNA
FunctionReceptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand; the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.
Length468
Molecular Weight52347
ReferenceNA
Hormone1036; 1044
PDB IDNA