| Primary information |
|---|
| ID | 31407 |
| Uniprot ID | O00482 |
| Description | Nuclear receptor subfamily 5 group A member 2;Alternative Name- Alpha-1-fetoprotein transcription factor;Alternative Name- Hepatocytic transcription factor;Alternative Name- B1-binding factor;hB1F;Alt |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Nucleus (Probable) |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes; a critical cis-element of their expression and regulation. May be responsable for the liver-specific activity of enhancer II; probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. |
| Length | 541 |
| Molecular Weight | 61331 |
| Reference | NA |
| Hormone | NA |
| PDB ID | 1YOK; 1YUC; 1ZDU; 2A66;
|