| Primary information |
|---|
| ID | 31365 |
| Uniprot ID | O75469 |
| Description | RecName- Nuclear receptor subfamily 1 group I member 2;Alternative Name- Orphan nuclear receptor PXR;Alternative Name- Pregnane X receptor;Alternative Name- Orphan nuclear receptor PAR1;Alternative Na |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics. |
| Length | 434 |
| Molecular Weight | 49762 |
| Reference | NA |
| Hormone | 1036; 1061; 1064; 1107; 1123; 1263 |
| PDB ID | 1ILG; 1ILH; 1M13; 1NRL; 1SKX; 2O9I;
|