| Primary information |
|---|
| ID | 31364 |
| Uniprot ID | Q62735 |
| Description | RecName- Bile acid receptor;Alternative Name- Farnesoid X-activated receptor;Alternative Name- Farnesol receptor HRR-1;Alternative Name- Nuclear receptor subfamily 1 group H member 4;Alternative Name- |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Nucleus (Probable) |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Receptor for bile acids such as chenodeoxycholic acid; lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus. |
| Length | 469 |
| Molecular Weight | 53935 |
| Reference | NA |
| Hormone | 1018; 1156; 1185; 1187; 1250; 1301; 1304 |
| PDB ID | 1OSV; 1OT7;
|