| Primary information |
|---|
| ID | 31358 |
| Uniprot ID | Q13133 |
| Description | RecName- Oxysterols receptor LXR-alpha;Alternative Name- Liver X receptor alpha;Alternative Name- Nuclear orphan receptor LXR-alpha;Alternative Name- Nuclear receptor subfamily 1 group H member 3; |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Nucleus (Potential) |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis. |
| Length | 447 |
| Molecular Weight | 50396 |
| Reference | NA |
| Hormone | 1306; 1332 |
| PDB ID | 1UHL;
|