| Primary information |
|---|
| ID | 31314 |
| Uniprot ID | P22449 |
| Description | RecName- Hepatocyte nuclear factor 4-alpha;HNF-4-alpha;Alternative Name- Transcription factor HNF-4;Alternative Name- Nuclear receptor subfamily 2 group A member 1;Alternative Name- Transcription fact |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | Phosphorylated in the recognition sequence R-R-S-S near the DNA-binding domain; phosphorylation results in decrease in DNA- binding activity. Phosphorylation of HNF4 depends on the diet and is decreased by a carbohydrate-rich diet and is increased by fasting. The N-terminus is blocked. |
| Function | Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin; apolipoprotein CIII; transthyretin genes and HNF1- alpha. May be essential for development of the liver; kidney and intestine. |
| Length | 474 |
| Molecular Weight | 52712 |
| Reference | NA |
| Hormone | NA |
| PDB ID | 1M7W;
|