| Primary information |
|---|
| ID | 31312 |
| Uniprot ID | P41235 |
| Description | RecName- Hepatocyte nuclear factor 4-alpha;HNF-4-alpha;Alternative Name- Transcription factor HNF-4;Alternative Name- Nuclear receptor subfamily 2 group A member 1;Alternative Name- Transcription fact |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. |
| Function | Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin; apolipoprotein CIII; transthyretin genes and HNF1- alpha. May be essential for development of the liver; kidney and intestine. |
| Length | 474 |
| Molecular Weight | 52785 |
| Reference | NA |
| Hormone | NA |
| PDB ID | 1PZL;
|