| Primary information |
|---|
| ID | 31311 |
| Uniprot ID | P49844 |
| Description | RecName- Glucocorticoid receptor;GR;Alternative Name- Nuclear receptor subfamily 3 group C member 1; |
| Organism | Xenopus laevis |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand; nuclear after ligand-binding |
| Developmental Stage | Rareley expressed between embryonic stages 17 and 24. Expression starts from stage 32. |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action- as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses; cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation. May be involved in early embryogenesis. |
| Length | 776 |
| Molecular Weight | 84977 |
| Reference | NA |
| Hormone | 1019; 1020; 1028; 1029; 1032; 1033; 1039; 1068; 10 |
| PDB ID | NA
|