| Primary information |
|---|
| ID | 31309 |
| Uniprot ID | P35547 |
| Description | RecName- Glucocorticoid receptor;GR;Alternative Name- Nuclear receptor subfamily 3 group C member 1; Fragment; |
| Organism | Ovis aries |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand; nuclear after ligand-binding |
| Developmental Stage | Detected in hypothalamus; anterior pituitary gland and adrenals in fetuses at days 60-70; 100-110; 125-130. In newborn; levels increased significantly in the hypothalamus and pituitary gland but decreased to undetectable levels in the adrenal. |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | Increased proteasome-mediated degradation in response to glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling. Sumoylated; this reduces transcription transactivation. |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action- as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses; cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation. |
| Length | 314 |
| Molecular Weight | 33562 |
| Reference | NA |
| Hormone | 1019; 1020; 1028; 1029; 1032; 1033; 1039; 1068; 10 |
| PDB ID | NA
|