| Primary information |
|---|
| ID | 31300 |
| Uniprot ID | P49843 |
| Description | RecName- Glucocorticoid receptor;GR;Alternative Name- Nuclear receptor subfamily 3 group C member 1; |
| Organism | Oncorhynchus mykiss |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei;Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae;Oncorhynchus. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand; nuclear after ligand-binding |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action- as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses; cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in controlling metabolic functions and osmoregulation. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation. |
| Length | 758 |
| Molecular Weight | 83345 |
| Reference | NA |
| Hormone | 1019; 1020; 1028; 1029; 1032; 1033; 1039; 1068; 10 |
| PDB ID | NA
|