| Primary information |
|---|
| ID | 31298 |
| Uniprot ID | P04150 |
| Description | RecName- Glucocorticoid receptor;GR;Alternative Name- Nuclear receptor subfamily 3 group C member 1; |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand; nuclear after ligand-binding |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | Increased proteasome-mediated degradation in response to glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser- 203-phosphorylated form is mainly cytoplasmic; and the Ser-211- phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211. Sumoylated; this reduces transcription transactivation. Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling. |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action- as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses; cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation. |
| Length | 777 |
| Molecular Weight | 85659 |
| Reference | NA |
| Hormone | 1019; 1020; 1021; 1022; 1023; 1026; 1028; 1029; 10 |
| PDB ID | 1M2Z; 1NHZ; 1P93; 3BQD; 3CLD;
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