| Primary information |
|---|
| ID | 31288 |
| Uniprot ID | Q62986 |
| Description | RecName- Estrogen receptor beta;ER-beta;Alternative Name- Nuclear receptor subfamily 3 group A member 2; |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Binds estrogens with an affinity similar to that of ER- alpha; and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER- alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action. |
| Length | 530 |
| Molecular Weight | 59152 |
| Reference | NA |
| Hormone | 1024; 1025; 1035; 1036; 1060; 1075; 1080; 1123; 11 |
| PDB ID | 1HJ1; 1QKN; 2J7X; 2J7Y;
|