| Primary information |
|---|
| ID | 31280 |
| Uniprot ID | Q92731 |
| Description | RecName- Estrogen receptor beta;ER-beta;Alternative Name- Nuclear receptor subfamily 3 group A member 2; |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1; and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
| Length | 530 |
| Molecular Weight | 59216 |
| Reference | NA |
| Hormone | 1024; 1025; 1034; 1035; 1036; 1057; 1058; 1059; 10 |
| PDB ID | 1L2J; 1NDE; 1QKM; 1U3Q; 1U3R; 1U3S; 1U9E; 1X76; 1X |