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31166 details
Primary information
ID31166
Uniprot IDQ95JF2
DescriptionGrowth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains- Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)].
OrganismAiluropoda melanoleuca
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;Ailuropoda.
Subcellular LocationCell membrane; single-pass type I membrane protein. Note=On growth hormone binding; GHR is ubiquitin
Developmental StageNA
SimilarityBelongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain.
Post Translational ModificationOn GH binding; phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. On ligand binding; ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization.
FunctionReceptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding; couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Length638
Molecular Weight70846
ReferenceNA
HormoneQ8HYE5
PDB IDNA