Detailed description page of Hmrbase2

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31154 details
Primary information
ID31154
Uniprot IDQ8SPP9
DescriptionThyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor).
OrganismSus scrofa
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular LocationMembrane; multi-pass membrane protein
Developmental StageNA
SimilarityBelongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 8 LRR (leucine-rich) repeats.
Post Translational ModificationNA
FunctionReceptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Length764
Molecular Weight86644
ReferenceNA
HormoneP01219; P01224
PDB IDNA