| Primary information |
|---|
| ID | 31109 |
| Uniprot ID | Q62893 |
| Description | Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30)(Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIStype II receptor) (MISRII) (MRII) (C14). |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Membrane; single-pass type I membrane protein |
| Developmental Stage | Expressed in the mesenchymal cells surrounding the Muellerian duct at embryonic days 14; 15; and 16 and in tubular and follicular structures of the fetal gonads. |
| Similarity | Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
| Post Translational Modification | NA |
| Function | On ligand binding; forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate; then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. |
| Length | 557 |
| Molecular Weight | 59749 |
| Reference | NA |
| Hormone | P49000 |
| PDB ID | NA
|