| Primary information |
|---|
| ID | 31067 |
| Uniprot ID | Q02092 |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains- Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Organism | Gallus gallus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. |
| Subcellular Location | Cell membrane; single-pass type I membrane protein. Note=On growth hormone binding; GHR is ubiquitin |
| Developmental Stage | NA |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Post Translational Modification | On GH binding; proteolytically cleaved; in vitro; to produce GHBP. On GH binding; phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. On ligand binding; ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization. Proteolytically cleaved; in vitro; to release the growth hormone-binding protein (GHBP). |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding; couples to; and activates the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. |
| Length | 608 |
| Molecular Weight | 68573 |
| Reference | NA |
| Hormone | P08998 |
| PDB ID | NA
|