| Primary information |
|---|
| ID | 31040 |
| Uniprot ID | P35379 |
| Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
| Organism | Ovis aries |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular Location | Isoform FSH-R1- Cell membrane; multi-pass membrane protein. Isoform FSH-R2- Cell membrane; multi-pas |
| Developmental Stage | NA |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
| Post Translational Modification | N-glycosylated; indirectly required for FSH-binding; possibly via a conformational change that allows high affinity binding of hormone. |
| Function | Receptor for follicle-stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH; but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. |
| Length | 695 |
| Molecular Weight | 78238 |
| Reference | NA |
| Hormone | P01218; P01227 |
| PDB ID | NA
|