| Primary information |
|---|
| ID | 31025 |
| Uniprot ID | P32238 |
| Description | Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR)(Cholecystokinin-1 receptor) (CCK1-R). |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Post Translational Modification | NA |
| Function | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion; smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Length | 428 |
| Molecular Weight | 47841 |
| Reference | NA |
| Hormone | P06307 |
| PDB ID | 1D6G; 1HZN; 1PB2;
|