| Primary information |
|---|
| ID | 30984 |
| Uniprot ID | P16310 |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains- Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular Location | Cell membrane; single-pass type I membrane protein. Isoform 2- Secreted. Note=On growth hormone bind |
| Developmental Stage | Expression is low at birth. Increases to adult levels after 5 weeks. |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Post Translational Modification | On GH binding; phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. Phosphorylation on either (or all of) Tyr-534; Tyr-566 and/or Tyr-627 is required for STAT5 activation. Phosphorylation on Tyr-333 would seem necessary for JAK2 activation. On ligand binding; ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization. |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding; couples to; and activates the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. |
| Length | 638 |
| Molecular Weight | 71237 |
| Reference | NA |
| Hormone | P01244 |
| PDB ID | NA
|