| Primary information |
|---|
| ID | 30983 |
| Uniprot ID | P15208 |
| Description | Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains- Insulin receptor subunit alpha; Insulin receptor subunitbeta]. |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular Location | Membrane; Single-pass type I membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 3 fibronectin type-III domains. Contains 1 protein kinase domain. |
| Post Translational Modification | Autophosphorylated on tyrosine residues in response to insulin. Phosphorylation of Tyr-989 is required for IRS1- and SHC1- binding. |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. |
| Length | 1372 |
| Molecular Weight | 155640 |
| Reference | NA |
| Hormone | P01326 |
| PDB ID | 1LK2;
|