| Primary information |
|---|
| ID | 30979 |
| Uniprot ID | P10912 |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains- Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cell membrane; single-pass type I membrane protein. GHBP- Secreted. Note=On growth hormone binding; |
| Developmental Stage | NA |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Post Translational Modification | The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17. On GH binding; phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. On ligand binding; ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding; couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. |
| Length | 638 |
| Molecular Weight | 71500 |
| Reference | NA |
| Hormone | P01241 |
| PDB ID | 1A22; 1AXI; 1HWG; 1HWH; 1KF9; 2AEW; 3HHR;
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