| Primary information |
|---|
| ID | 30978 |
| Uniprot ID | P06213 |
| Description | Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains- Insulin receptor subunit alpha; Insulin receptor subunitbeta]. |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Membrane; Single-pass type I membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. |
| Post Translational Modification | After being transported from the endoplasmic reticulum to the Golgi apparatus; the single glycosylated precursor is further glycosylated and then cleaved; followed by its transport to the plasma membrane. Autophosphorylated on tyrosine residues in response to insulin. Phosphorylation of Tyr-999 is required for IRS1- and SHC1- binding. |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit; or indirectly via IRS1. |
| Length | 1382 |
| Molecular Weight | 156307 |
| Reference | NA |
| Hormone | P01308 |
| PDB ID | 1GAG; 1I44; 1IR3; 1IRK; 1P14; 1RQQ; 2AUH; 2B4S; 2D |