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30954 details
Primary information
ID30954
Uniprot IDQ63931
DescriptionCholecystokinin type A receptor (CCK-A receptor) (CCK-AR)(Cholecystokinin-1 receptor) (CCK1-R).
OrganismCavia porcellus
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia.
Subcellular LocationCell membrane; multi-pass membrane protein
Developmental StageNA
SimilarityBelongs to the G-protein coupled receptor 1 family.
Post Translational ModificationNA
FunctionReceptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion; smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Length430
Molecular Weight48211
ReferenceNA
HormoneNA
PDB IDNA