| Primary information |
|---|
| ID | 30766 |
| Uniprot ID | P18089 |
| Description | Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2Badrenoreceptor) (Alpha-2 adrenergic receptor subtype C2). |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Post Translational Modification | NA |
| Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine norepinephrine epinephrine = oxymetazoline dopamine p-tyramine = phenylephrine serotonin p-synephrine / p-octopamine. For antagonists; the rank order is yohimbine chlorpromazine phentolamine mianserine spiperone prazosin alprenolol propanolol pindolol. |
| Length | 450 |
| Molecular Weight | 49954 |
| Reference | NA |
| Hormone | 1230; 1290 |
| PDB ID | 2CVA;
|