| Primary information |
|---|
| ID | 30761 |
| Uniprot ID | P08913 |
| Description | Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular Location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | NA |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Post Translational Modification | NA |
| Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline clonidine epinephrine norepinephrine phenylephrine dopamine p-synephrine p-tyramine serotonin = p-octopamine. For antagonists; the rank order is yohimbine phentolamine = mianserine chlorpromazine = spiperone = prazosin propanolol alprenolol = pindolol. |
| Length | 450 |
| Molecular Weight | 48957 |
| Reference | NA |
| Hormone | 1230; 1290 |
| PDB ID | 1HLL; 1HO9; 1HOD; 1HOF;
|