| Primary information |
|---|
| ID | 30181 |
| Uniprot ID | P33242 |
| Description | Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein)(Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1)(Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat-b |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular Location | Nucleus |
| Developmental Stage | Expressed during early embryonic development. Expressed only in undifferentiated embryonal carcinoma cells. |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Post Translational Modification | NA |
| Function | Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A; CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO- NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phospholipids with a phosphatidylinositol (PI) headgroup; in particular phosphatidyl(3;4)bisphosphate; phosphatidyl(3;5)bisphosphate and phosphatidyl(3;4;5)triphosphate. |
| Length | 462 |
| Molecular Weight | 51946 |
| Reference | NA |
| Hormone | NA |
| PDB ID | 1YMT; 1YP0; 2FF0;
|