| Primary information |
|---|
| ID | 17396 |
| Uniprot ID | P49765 |
| Description | Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted Note=Secreted but remains associated to cells or to the extracellular matrix unless release |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed in all tissues except liver. Highest levels found in heart; skeletal muscle and pancreas. |
| Post Translational Modification | VEGF-B186 is O-glycosylated. |
| Function | Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. |
| Length | 207 |
| Molecular Weight | 21602 |
| Name | Vascular endothelial growth factor B |
| Sequence | VSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA |
| Sequence map | 25-27 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | O14786; P17948-2; P17948 |
| Domain | NA |
| Pharmaceutical Use | NA
|