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17378 details
Primary information
ID17378
Uniprot IDP08112
DescriptionTransforming growth factor beta-2 proprotein (BSC-1 cell growth inhibitor) (Polyergin) [Cleaved into- Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
OrganismHomo sapiens
TxonomyChlorocebus ; Cercopithecinae; Cercopithecidae ; Cercopithecoidea ; Catarrhini; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires; Boreoeutheria; Eutheria; Theria; Mammalia ; Amniota; Tetrapoda; Dipnotetrapodomorpha; Sarcopterygii; Euteleostomi; Teleostomi; Gnathostomata; Vertebrata; Craniata ; Chordata ; Deuterostomia; Bilateria; Eumetazoa; Metazoa ; Opisthokonta; Eukaryota ; cellular organisms
Subcellular Location[Latency-associated peptide]- Secreted; extracellular space; extracellular matrix
Developmental StageNA
SimilarityNA
Tissue SpecificityNA
Post Translational Modification[Transforming growth factor beta-2]- The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains; whic
Function[Transforming growth factor beta-2 proprotein]- Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains; which constitute the regulatory and active subunit of TGF-beta-2; respectively.
Length414
Molecular Weight47748
NameTransforming growth factor beta-2 proprotein
SequenceLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
Sequence map26-54
PDB IDNA
DrugpediaNA
ReceptorP37173; Q03167; Q6EMK4
DomainNA
Pharmaceutical UseNA