| Primary information |
|---|
| ID | 17377 |
| Uniprot ID | P01137 |
| Description | Transforming growth factor beta-1 proprotein [Cleaved into- Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | [Latency-associated peptide]- Secreted; extracellular space; extracellular matrix |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Highly expressed in bone |
| Post Translational Modification | Transforming growth factor beta-1 proprotein- The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide |
| Function | Transforming growth factor beta-1 proprotein- Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains; which constitute the regulatory and active subunit of TGF-beta-1; respectively. |
| Length | 390 |
| Molecular Weight | 44341 |
| Name | Latency-associated peptide |
| Sequence | STCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRR |
| Sequence map | 34-38 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P37173; Q6EMK4 |
| Domain | [Latency-associated peptide]: The 'straitjacket' a |
| Pharmaceutical Use | NA
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