| Primary information |
|---|
| ID | 17371 |
| Uniprot ID | Q14242 |
| Description | P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed on neutrophils; monocytes and most lymphocytes. |
| Post Translational Modification | Displays complex; core-2; sialylated and fucosylated O-linked oligosaccharides; at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialyla |
| Function | A SLe(x)-type proteoglycan; which through high affinity; calcium-dependent interactions with E-; P- and L-selectins; mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. |
| Length | 412 |
| Molecular Weight | 43201 |
| Name | P-selectin glycoprotein ligand 1 |
| Sequence | ATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP |
| Sequence map | 48-52 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q9BZZ2; P16581; P16109; P14151 |
| Domain | NA |
| Pharmaceutical Use | NA
|