| Primary information |
|---|
| ID | 17349 |
| Uniprot ID | Q8NBP7 |
| Description | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Cytoplasm. Secreted Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=A |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed in neuro-epithelioma; colon carcinoma; hepatic and pancreatic cell lines; and in Schwann cells. |
| Post Translational Modification | Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation. |
| Function | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members- low density lipoprotein receptor (LDLR); very low density lipoprotein receptor (VLDLR); apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2); and promotes their degradation in intracellular acidic compartments |
| Length | 692 |
| Molecular Weight | 74286 |
| Name | Proprotein convertase subtilisin/kexin type 9 |
| Sequence | IPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQELQ |
| Sequence map | 164-32 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P01130 |
| Domain | The C-terminal domain (CRD) is essential for the L |
| Pharmaceutical Use | NA
|