| Primary information |
|---|
| ID | 17339 |
| Uniprot ID | Q9GZP0 |
| Description | Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into- Platelet-derived growth factor D; latent form (PDGFD latent form); Platelet-derived growth factor D; receptor-binding form (PDGFD receptor-binding form)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | Not detectable in the earliest stages of glomerulogenesis; and not detected in the metanephric blastema or surrounding cortical interstitial cells. In later stages of glomerulogenesis; localized to ep |
| Similarity | NA |
| Tissue Specificity | Expressed at high levels in the heart; pancreas; adrenal gland and ovary and at low levels in placenta; liver; kidney; prostate; testis; small intestine; spleen and colon. In the kidney; expressed by |
| Post Translational Modification | Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage afte |
| Function | Growth factor that plays an essential role in the regulation of embryonic development; cell proliferation; cell migration; survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment; increased interstitial pressure; and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis; including influx of monocytes and macrophages and production of extracellular matrix. |
| Length | 370 |
| Molecular Weight | 42848 |
| Name | Platelet-derived growth factor D; latent form |
| Sequence | DTSATPQSASIKALRNANLRRDESNHLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDTVEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR |
| Sequence map | 25-10 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P09619 |
| Domain | NA |
| Pharmaceutical Use | NA
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