| Primary information |
|---|
| ID | 17325 |
| Uniprot ID | P56975 |
| Description | Pro-neuregulin-3; membrane-bound isoform (Pro-NRG3) [Cleaved into- Neuregulin-3 (NRG-3)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | [Pro-neuregulin-3; membrane-bound isoform]- Cell membrane |
| Developmental Stage | Isoform 3 is expressed in fetal brain but not in other fetal tissues. |
| Similarity | NA |
| Tissue Specificity | Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart; placenta; lung; liver; skeletal muscle; kidney; pancreas |
| Post Translational Modification | Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.; Extensive glycosylation precedes the proteolytic cleavage. Isoform 3 is |
| Function | Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor; ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. |
| Length | 720 |
| Molecular Weight | 77901 |
| Name | Pro-neuregulin-3; membrane-bound isoform |
| Sequence | SEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK |
| Sequence map | 13 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q15303 |
| Domain | The cytoplasmic domain may be involved in the regu |
| Pharmaceutical Use | NA
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