| Primary information |
|---|
| ID | 17291 |
| Uniprot ID | Q6ZMJ4 |
| Description | Interleukin-34 (IL-34) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Detected in the sinusoidal epithelium in the red pulp of spleen |
| Post Translational Modification | NA |
| Function | Cytokine that promotes the proliferation; survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines; and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation; and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. |
| Length | 242 |
| Molecular Weight | 27482 |
| Name | Interleukin-34 |
| Sequence | EPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP |
| Sequence map | 25-02 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P07333 |
| Domain | NA |
| Pharmaceutical Use | NA
|